Figure 2.

Characterisation of the Atp7a^T985I mouse phenotype shows no global motor abnormalities. (A) Kaplan Meir survival curves for wild type (+/Y) and knock in (KI/Y) males revealed no significant differences in survival rate between the two groups. (B) Body weight (g) and the total number of animals studied for each age point (months) are shown. (C) Rotarod test at ages 15 (n=35/genotype) and 18 months old (n=16/genotype). The best performance out of three runs for their ability to successfully continue running on an accelerated program (from 4 to 40 rpm over 300 s) was recorded and the mean value for each genotype is shown as the maximum latency to fall.