Fig. 2. Nanoprecipitation of hyp-polydendrons. (A) Schematic of nano-precipitation from THF (good solvent) into water (poor solvent). Dissolved and expanded hyp-polydendrons collapse, forming self-assembling nuclei that form stable nanoparticles aqueous environments; (B) schematic representation of hyp-polydendron nanoprecipitates containing (i) 100% dendron initiator, (ii) a 50 : 50 molar ratio of G₂ dendron–PEG₁₆ initiators, and (iii) 100% PEG₁₆ initiator; (C) scanning electron microscopy images of hyp-polydendron nanoprecipitates (initial concentration in THF = 5 mg mL^–1, final aqueous concentration = 1 mg mL^–1) with varying G₂ dendron–PEG₁₆ molar ratios: (i) 100 : 0, (ii) 90 : 10, (iii) 50 : 50, and (iv) 25 : 75; (D) atomic force microscopy of hyp-polydendron nanoprecipitate particles (initial concentration in THF = 5 mg mL^–1, final aqueous concentration = 1 mg mL^–1): (i) size image for nanoprecipitates generated from a G₂ dendron–PEG₁₆ molar ratio of 100 : 0, (ii) contour image of nanoprecipitates with a G₂ dendron–PEG₁₆ molar ratio of 25 : 75.