Table IV.
Demographic characteristics of VANISH patients as of September 27, 2016
| Variable | Overall, N = 139 | Primary cohort, N = 114 | Exploratory cohort, N = 25 |
|---|---|---|---|
| Age at baseline, mean (SD), years | 20.3 (8.9) | 21.1 (9.5) | 16.6 (4.5) |
| Sex, n (%) | |||
| Female | 60 (43) | 51 (45) | 9 (36) |
| Male | 79 (57) | 63 (55) | 16 (64) |
| Race, n (%) | |||
| White | 134 (96) | 109 (96) | 25 (100) |
| Black | 0 (0) | ||
| Other | 5 (4) | 5 (4) | |
| Maximal LV Wall Thickness Z-Score, mean (SD) | 6.0 (4.1) | 6.8 (4.2) | 2.0 (0.7) |
| E″ lateral Z-Score, mean (SD) | −1.6 (1.4) | −1.8 (1.3) | −0.4 (1.0) |
| LVEF (%), mean (SD), years | 65 (7) | 67 (7) | 63 (4) |
| Peak VO2, mean (SD), mL/kg/min | 33.8 (9.8) | 32.8 (10.0) | 37.3 (8.3) |
| NYHA class, n (%) | |||
| I | 134 (96) | 109 (96) | 25 (100) |
| II | 5 (4) | 5 (4) | |
| Gene, n (%) | |||
| MYBPC3 | 67 (49) | 55 (50) | 12 (48) |
| MYH7 | 47 (35) | 37 (33) | 10 (40) |
| TNNT2 | 9 (7) | 9 (8) | 0 |
| TNNI3 | 5 (4) | 3 (3) | 0 |
LV, Left ventricle; EF, ejection fraction; VO2, volume of oxygen consumption; NYHA, New York Heart Association; MYBPC3, myosin binding protein C; MYH7, myosin heavy chain; TNNT2, cardiac troponin T; TNNI3, cardiac troponin I.