. Author manuscript; available in PMC: 2017 Sep 6.

Published in final edited form as: Am Heart J. 2017 Feb 16;187:145–155. doi: 10.1016/j.ahj.2017.02.008

Table V.

Outcome domains and components for the primary composite endpoint

Domain	Component outcomes
Serum biomarkers of myocardial injury and stress	High-sensitivity cardiac troponin NTproBNP
Cardiac morphology	CMR LV mass^* CMR LA volume^* CMR end-diastolic LV volume^* CMR end-systolic LV volume^* Echocardiographic maximum LV wall thickness z-score
Cardiac function	Echocardiographic E′ z-score Echocardiographic S′ z-score

NTproBNP, Amino terminal propeptide of B-type natriuretic peptide; CMR, cardiac magnetic resonance imaging; LA, left atrium; LV, left ventricle.

CMR metrics will be indexed to body surface area; echocardiographic z-scores to substitute if CMR imaging unavailable.