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. 2017 Jul 22;6(7):e003693. doi: 10.1161/JAHA.116.003693

Figure 1.

Figure 1

MT1‐MMP (membrane‐type 1 matrix metalloproteinase) heterozygosity promotes atherosclerosis. A, Mmp14 +/+ Apoe −/− mice and Mmp14 +/− Apoe −/− mice were fed a Western diet for 12 weeks beginning at 8 weeks of age. Body weight (g) at the end of study. B, Percentage of fat mass (wt/wt) of total (epididymal plus inguinal) and epididymal fat pads. C, Fasting serum cholesterol (total and direct low‐density lipoprotein) levels. Mean±SEM, n=8 and n=10, respectively; *P<0.05. D, Atherosclerotic lesions detected with Oil Red O staining in Mmp14 +/+ Apoe −/−and Mmp14 +/− Apoe −/− male mice. Arrows point to the increased atherogenesis distributed in abdominal aorta and iliac arteries specifically, as found in Mmp14 +/− Apoe −/− mice. E and F, Oil Red O–positive atherosclerotic plaque areas quantified in all aortic trees and abdominal aortas in male mice (n=7 each) and female mice (n=4 and n=10). Mean±SEM, *P<0.05, **P<0.005, ***P<0.0005. a. indicates artery.