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. 2017 Jul 22;6(7):e003693. doi: 10.1161/JAHA.116.003693

Figure 3.

Figure 3

Vascular smooth muscle cell MT1‐MMP (membrane‐type 1 matrix metalloproteinase) gene targeting promotes atherosclerosis and aneurysm formation. A, Whole arterial trees assessed for Oil Red O–positive atherosclerotic plaque area (red). Arrows point to atherosclerotic aneurysms. Representative arterial trees from SM22α‐Cre(−)MMP14 F/ FA poe −/− and SM22α‐Cre(+)MMP14 F/ FA poe −/− mice are shown; n=13 and n=20, respectively. B, Higher magnification of aortic aneurysms found in SM22α‐Cre(+)MMP14 F/ FA poe −/− mice. C, Percentage of plaque area in Cre(−)Mmp14 F/ FA poe −/−, SM22α‐Cre(+)Mmp14 F/ FA poe −/− , aP2‐Cre‐ERT2(+)Mmp14 F/ FA poe −/− mice, males and females (n=8, n=13, and n=4 in male mice, and n=5, n=7, and n=7 in female mice, respectively). *P<0.05, ***P<0.0005.