Table 4.

Adipokines and Parental History of Obesity or DM Before Age 60

	Parental Obesity				Parental DM
	Age/Sex‐Adjusted		Multivariable‐Adjusted		Age/Sex‐Adjusted		Multivariable‐Adjusted
	Estimate (SE)	P Value	Estimate (SE)	P Value	Estimate (SE)	P Value	Estimate (SE)	P Value
RBP4	0.0189 (0.0098)	0.05	0.0098 (0.0097)	0.31	0.0563 (0.0170)	0.001	0.0415 (0.0163)	0.01
FABP4	0.0945 (0.0167)	<0.001	0.0344 (0.0147)	0.02	0.0829 (0.0270)	0.002	0.0372 (0.0232)	0.11
Fetuin A	0.0005 (0.0144)	0.97	−0.0029 (0.0147)	0.84	0.0247 (0.0231)	0.29	0.0225 (0.0235)	0.34
Leptin	0.1196 (0.0286)	<0.001	−0.0370 (0.0225)	0.10	0.1096 (0.0516)	0.03	0.0255 (0.0366)	0.49
LEP‐R	0.0107 (0.0183)	0.56	0.0407 (0.0180)	0.02	−0.0008 (0.0307)	0.98	0.0135 (0.0296)	0.65
Adiponectin	−0.0329 (0.0250)	0.19	0.0134 (0.0239)	0.57	−0.1298 (0.0417)	0.002	−0.0945 (0.0398)	0.02

Adipokines modeled as continuous, natural logarithm–transformed variables with estimates indicating increase in mean transformed adipokine concentration for each additional parent with obesity or DM (separate analyses for each). Parental disease modeled as an ordinal variable taking on the values of 0, 1, or 2 parents with condition before age 60. Models were adjusted first for age and sex. The multivariable model was adjusted for age, sex, body mass index, systolic BP, diastolic BP, BP treatment, ratio of total/high‐density lipoprotein cholesterol, and smoking status. BP indicates blood pressure; DM, diabetes mellitus; LEP‐R, leptin receptor.