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. 2017 Jul 3;6(7):e005092. doi: 10.1161/JAHA.116.005092

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Correlation data to show (A) serum creatinine (SCr) at day 2 vs Sirius red percentage per tissue field (indicative of fibrosis) at day 28, (B) the estimated creatinine clearance at day 2 vs Sirius red percentage per tissue field (indicative of fibrosis) at day 28, and (C) area under the curve (AUC) of SCr concentration (from day 1 to day 28) vs Sirius red percentage per tissue field (indicative of fibrosis) at day 28. All animal data (sham+vehicle, ischemia reperfusion injury [IRI]+vehicle, and IRI+IKK16 24 hours postreperfusion) are included in these graphs. AUC was calculated after plotting the values of SCr at day 1, 2, 7, 14, 21, and 28 postreperfusion. Linear regressions were calculated by the least squares method and their significance were estimated by Fisher F test. P<0.05 was considered to be significant.