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. 2017 Jul 5;6(7):e005235. doi: 10.1161/JAHA.116.005235

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Differential prognostication of circulating biomarkers for all‐cause death in (A) non‐CKD and (B) CKD individuals; and for cardiovascular death or event in (C) non‐CKD and (D) CKD individuals. X‐axis represents Harrell's c‐statistics, and P values are for likelihood ratio tests comparing the nested models. BNP indicates brain natriuretic peptide; CKD, chronic kidney disease; hs‐TnT, high‐sensitivity troponin T; NT‐pro‐BNP, N‐terminal‐pro‐brain natriuretic peptide. *P<0.05 1 biomarker model compared with base model, including age, sex, race, diabetes mellitus, hypertension, smoking, and total and HDL cholesterol. ^† P<0.05 2 biomarker model compared to base model+BNP. ^‡ P<0.05 2 biomarker model compared to base model+NT‐pro‐BNP. ^§ P<0.05 2 biomarker model compared with base model+hs‐TnT.