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. 2017 Jul 18;6(7):e005835. doi: 10.1161/JAHA.117.005835

Figure 3.

Figure 3

Hazard ratio with 95% confidence interval of outcomes, using overall patients enrolled in included trials, based on valvular status (VHD vs non‐VHD). ARISTOTLE, Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation; CI, confidence interval; ENGAGE AF, Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation; IV, instrumental variable; RE‐LY, Randomized Evaluation of Long‐Term Anticoagulation Therapy; ROCKET AF, Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation; VHD indicates valvular heart disease.