Table 4.
Predictive Performance, Reclassification, and Discrimination
| AUC (95% CI) | P Value | cNRI (95% CI) | P Value | IDI (95% CI) | P Value | Calibration χ2 (P Value) | |
|---|---|---|---|---|---|---|---|
| Compared with RF only | |||||||
| RF only | 0.769 (0.716–0.823) | ··· | ··· | ··· | ··· | ··· | 5.80 (0.67) |
| RF+AF‐GS | 0.791 (0.741–0.841) | 0.055 | 0.468 (0.240–0.696) | <0.0001 | 0.029 (0.009–0.049) | 0.005 | 2.69 (0.95) |
| RF+BA‐GS | 0.784 (0.732–0.835) | 0.222 | 0.309 (0.079–0.538) | 0.009 | 0.022 (0.006–0.038) | 0.007 | 4.65 (0.79) |
| RF+both GSs | 0.803 (0.754–0.853) | 0.031 | 0.524 (0.298–0.751) | <0.0001 | 0.050 (0.024–0.076) | 0.0002 | 3.60 (0.89) |
| Compared with RF+BA‐GS | |||||||
| RF+both GSs | 0.803 (0.754–0.853) | 0.048 | 0.474 (0.247–0.702) | <0.0001 | 0.028 (0.009–0.047) | 0.003 | 3.60 (0.89) |
| Compared with RF+AF‐GS | |||||||
| RF+both GSs | 0.803 (0.754–0.853) | 0.219 | 0.252 (0.021–0.483) | 0.032 | 0.021 (0.007–0.036) | 0.004 | 3.60 (0.89) |
RFs for atrial fibrillation from model 2: age; sex; body mass index; height; weight; smoking status (in the previous 12 months and ever); systolic blood pressure; diastolic blood pressure; hypertension; diabetes mellitus; coronary artery disease; dyslipidemia; congestive heart failure; valvular heart disease; chronic renal failure; chronic obstructive pulmonary disease; and relative lymphocytes, neutrophils, and monocytes. AF‐GS indicates atrial fibrillation gene score; AUC indicates area under the receiver operating characteristic curve; BA‐GS, biological age gene score; cNRI, continuous net reclassification improvement index; GS, gene score; IDI, integrated discrimination improvement index; RF, risk factor.