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. 2017 Jul 19;6(7):e006304. doi: 10.1161/JAHA.117.006304

Table 2.

Specific Subgroup Analysis for New‐Onset HZ (N=138 045)

Variable Event Person‐Y Incidence Rate (Per 1000 Person‐Y) Crude HR (95%CI) P Value Adjusted HRa (95%CI) P Value
RA
No 4936 683 102 7.2 1.0 (reference) 1.0 (reference)
Yes 2892 158 161 18.3 2.54 (2.42‐2.66) <0.0001b 2.53 (2.42‐2.65) <0.0001b
Age, y
<45 1004 245 131 4.1 1.0 (reference) 1.0 (reference)
45 to 64 4547 424 577 10.7 2.62 (2.45‐2.81) <0.0001b 2.37 (2.21‐2.54) <0.0001
≥65 2277 171 555 13.3 3.27 (3.03‐3.52) <0.0001b 2.74 (2.53‐2.98) <0.0001
Sex
Female 6232 660 427 9.4 1.0 (reference) 1.0 (reference)
Male 1596 180 836 8.8 0.94 (0.89‐0.99) 0.02b 0.90 (0.85‐0.95) 0.0003b
Atrial fibrillation
No 7740 834 066 92.8 1.0 (reference) 1.0 (reference)
Yes 88 7197 122 1.33 (1.08‐1.64) 0.008b 0.94 (0.76‐1.16) 0.54
Chronic kidney disease
No 7658 827 437 9.3 1.0 (reference) 1.0 (reference)
Yes 170 13 826 12.3 1.34 (1.15‐1.56) 0.0002b 0.92 (0.79‐1.07) 0.29
COPD
No 4841 610 232 7.9 1.0 (reference) 1.0 (reference)
Yes 2987 231 031 12.9 1.63 (1.56‐1.71) <0.0001b 1.29 (1.23‐1.35) <0.0001b
Diabetes mellitus
No 6141 711 755 8.6 1.0 (reference) 1.0 (reference)
Yes 1687 129 508 13.0 1.52 (1.44‐1.60) <0.0001b 1.05 (0.99‐1.12) 0.10
Dyslipidemia
No 5413 662 131 81.8 1.0 (reference) 1.0 (reference)
Yes 2415 179 132 135.0 1.66 (1.58‐1.74) <0.0001b 1.21 (1.14‐1.27) <0.0001b
Hypertension
No 4480 580 872 77.1 1.0 (reference) 1.0 (reference)
Yes 3348 260 391 129.0 1.67 (1.60‐1.75) <0.0001b 1.12 (1.06‐1.7) <0.0001b
Statins used
No 6921 777 543 89.0 1.0 (reference) 1.0 (reference)
Yes 907 63 720 142.3 1.62 (1.51‐1.74) <0.0001b 1.05 (0.97‐1.14) 0.23

COPD indicates chronic obstructive pulmonary disease; HR, hazard ratio; HZ, herpes zoster; RA, rheumatoid arthritis.

a

Adjusted for age, sex, atrial fibrillation, chronic kidney disease, COPD, diabetes mellitus, dyslipidemia, and hypertension.

b

A P‐value of <0.05 was indicated that variable was associated with herpes zoster.