Table 2.
Variable | Event | Person‐Y | Incidence Rate (Per 1000 Person‐Y) | Crude HR (95%CI) | P Value | Adjusted HRa (95%CI) | P Value |
---|---|---|---|---|---|---|---|
RA | |||||||
No | 4936 | 683 102 | 7.2 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 2892 | 158 161 | 18.3 | 2.54 (2.42‐2.66) | <0.0001b | 2.53 (2.42‐2.65) | <0.0001b |
Age, y | |||||||
<45 | 1004 | 245 131 | 4.1 | 1.0 (reference) | 1.0 (reference) | ||
45 to 64 | 4547 | 424 577 | 10.7 | 2.62 (2.45‐2.81) | <0.0001b | 2.37 (2.21‐2.54) | <0.0001 |
≥65 | 2277 | 171 555 | 13.3 | 3.27 (3.03‐3.52) | <0.0001b | 2.74 (2.53‐2.98) | <0.0001 |
Sex | |||||||
Female | 6232 | 660 427 | 9.4 | 1.0 (reference) | 1.0 (reference) | ||
Male | 1596 | 180 836 | 8.8 | 0.94 (0.89‐0.99) | 0.02b | 0.90 (0.85‐0.95) | 0.0003b |
Atrial fibrillation | |||||||
No | 7740 | 834 066 | 92.8 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 88 | 7197 | 122 | 1.33 (1.08‐1.64) | 0.008b | 0.94 (0.76‐1.16) | 0.54 |
Chronic kidney disease | |||||||
No | 7658 | 827 437 | 9.3 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 170 | 13 826 | 12.3 | 1.34 (1.15‐1.56) | 0.0002b | 0.92 (0.79‐1.07) | 0.29 |
COPD | |||||||
No | 4841 | 610 232 | 7.9 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 2987 | 231 031 | 12.9 | 1.63 (1.56‐1.71) | <0.0001b | 1.29 (1.23‐1.35) | <0.0001b |
Diabetes mellitus | |||||||
No | 6141 | 711 755 | 8.6 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 1687 | 129 508 | 13.0 | 1.52 (1.44‐1.60) | <0.0001b | 1.05 (0.99‐1.12) | 0.10 |
Dyslipidemia | |||||||
No | 5413 | 662 131 | 81.8 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 2415 | 179 132 | 135.0 | 1.66 (1.58‐1.74) | <0.0001b | 1.21 (1.14‐1.27) | <0.0001b |
Hypertension | |||||||
No | 4480 | 580 872 | 77.1 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 3348 | 260 391 | 129.0 | 1.67 (1.60‐1.75) | <0.0001b | 1.12 (1.06‐1.7) | <0.0001b |
Statins used | |||||||
No | 6921 | 777 543 | 89.0 | 1.0 (reference) | 1.0 (reference) | ||
Yes | 907 | 63 720 | 142.3 | 1.62 (1.51‐1.74) | <0.0001b | 1.05 (0.97‐1.14) | 0.23 |
COPD indicates chronic obstructive pulmonary disease; HR, hazard ratio; HZ, herpes zoster; RA, rheumatoid arthritis.
Adjusted for age, sex, atrial fibrillation, chronic kidney disease, COPD, diabetes mellitus, dyslipidemia, and hypertension.
A P‐value of <0.05 was indicated that variable was associated with herpes zoster.