Table 4.
Multivariate Analysis for Risk for Stroke Among RA Patients With Different HZ Phenotypes
| Variable | N | Event | Person‐Y | Incidence Rate (Per 1000 Person‐Y) | Crude HR (95%CI) | P Value | Adjusted HRa (95%CI) | P Value |
|---|---|---|---|---|---|---|---|---|
| RA without HZ | 5475 | 186 | 20 366 | 91.3 | 1.0 (reference) | 1.0 (reference) | ||
| RA with HZ | 2744 | 116 | 9982 | 116 | 1.27 (1.01‐1.60) | 0.04b | 1.27 (1.00‐1.60) | 0.047b |
| HZ with neurological complication | 721 | 38 | 2503 | 152 | 1.66 (1.17‐2.35) | 0.004b | 1.54 (1.09‐2.19) | 0.015b |
| HZ with cranial complication | 185 | 6 | 625 | 96.1 | 1.05 (0.47‐2.37) | 0.91 | 0.85 (0.38‐1.91) | 0.68 |
| HZ with other complication | 229 | 9 | 700 | 129 | 1.42 (0.73‐2.78) | 0.30 | 1.19 (0.61‐2.34) | 0.60 |
| HZ without complication | 1609 | 63 | 6154 | 102 | 1.12 (0.84‐1.49) | 0.44 | 1.20 (0.90‐1.60) | 0.20 |
HR indicates hazard ratio; HZ, herpes zoster; RA, rheumatoid arthritis.
a
Adjusted for age, sex, atrial fibrillation, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, dyslipidemia, and hypertension.
b
A P‐value of <0.05 was indicated that HZ‐related complication was associated with stroke.