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. 2017 Jul 19;6(7):e006349. doi: 10.1161/JAHA.117.006349

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ataxia telangiectasia mutated (ATM) haplodeficiency increased cardiac fibrosis post myocardial infarction (MI). A, Representative Masson's trichrome staining of cardiac sections in ATM ^+/+ and ATM ^+/− mice at day 28 after sham or MI surgery. B, Wall thickness of scar tissue and quantitative analysis of (C) infarct size at day 28 after MI in ATM ^+/+ and ATM ^+/− mice. D, Expansion index of left ventricle at 28 days after MI in ATM ^+/+ and ATM ^+/− mice. E, Quantification of fibrosis in infarcted and noninfarcted areas 28 days after MI in ATM ^+/+ and ATM ^+/− mice. F, Representative picrosirius red–stained sections of infarct, border, and remote areas 28 days after MI in ATM ^+/+ and ATM ^+/− mice. n=7 in the ATM ^+/+ MI group, n=6 in the ATM ^+/− group. *P<0.05 vs the ATM ^+/+ MI group. NS indicates not significant. Bar=50 μm.