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. 2017 Jul 31;7(9):1291–1301. doi: 10.1002/2211-5463.12265

Figure 4.

Figure 4

SIRT6 positively regulates MMP9 abundance in OS cells. (A) The differences in the expression of MMP9 between four different OS cell lines (Saos‐2, MG‐63, U2OS and 143B) and NB specimens. *P < 0.05. (B) Saos‐2 cells that were transfected with scrambled siRNA (siNC) or siSIRT6 were confirmed by immunoblotting. SIRT6 knockdown down‐regulated the level of MMP9 in Saos‐2 cells. *P < 0.05. (C) MG‐63 cells that were transfected with control vector or pc‐DNA3.1‐SIRT6 were confirmed by immunoblotting. SIRT6 overexpression increased the level of MMP9 in MG‐63 cells. *P < 0.05.