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Iowa and Danish RA pedigrees. (A) Iowa pedigree showing dominant inheritance of the agenesis phenotype. (B) Danish pedigree showing transmission of the de novo GREB1L variant to both fetuses. M1, Iowa variant; M2, Danish variant; +, presence, −, absence, *, likely origin of the Iowa mutation. II-2 shaded female (Iowa) and III-3,4 shaded males (Denmark), family members with incomplete penetrance.
