Figure 4.

greb1l mutants have edema and abnormal pronephros development. (A–F) Lateral views of live larvae at the indicated stage and of the indicated genotype. (B) At 4 dpf, mutants exhibit edema particularly around the heart and eyes. (D) 2 dpf mutant embryos have dilated and kinked tubules (F: dotted lines). At 3 dpf, in mutant embryos the kidney remains dilated (dotted lines) and cysts are evident in most cases (red dotted circle).