Table 1. Key proteins required for helicase loading and activation.
| Drosophila | Mammalian homolog | Budding yeast homolog | Function |
|---|---|---|---|
| ORC1 | ORC1 | Orc1 | Helicase loading |
| ORC2 | ORC2 | Orc2 | Helicase loading |
| Latheo | ORC3 | Orc3 | Helicase loading |
| ORC4 | ORC4 | Orc4 | Helicase loading |
| ORC5 | ORC5 | Orc5 | Helicase loading |
| ORC6 | ORC6 | Orc6 | Helicase loading |
| CDC6 | CDC6 | Cdc6 | Helicase loading |
| Double parked (DUP) | CDT1 | Cdt1 | Helicase loading |
| MCM2 | MCM2 | Mcm2 | Helicase |
| MCM3 | MCM3 | Mcm3 | Helicase |
| Disc proliferation abnormal (DPA) | MCM4 | Mcm4 | Helicase |
| MCM5 | MCM5 | Mcm5 | Helicase |
| MCM6 | MCM6 | Mcm6 | Helicase |
| MCM7 | MCM7 | Mcm7 | Helicase |
| MCM10 | MCM10 | Mcm10 | Helicase activation |
| CDC45 | CDC45 | Cdc45 | Helicase activation/helicase |
| SLD5 | SLD5 | Sld5 | Helicase activation/helicase |
| PSF1 | PSF1 | Psf1 | Helicase activation/helicase |
| PSF2 | PSF2 | Psf2 | Helicase activation/helicase |
| PSF3 | PSF3 | Psf3 | Helicase activation/helicase |
| MUS101 | TopBP1 | Dpb11 | Helicase activation/helicase |
| RECQ4 | RECQL4 | Sld2 | Helicase activation |
| (Not identified) | Treslin/ticcr | Sld3 | Helicase activation |