Figure 3.

Secondary structural context of mutational effects. (A) Density plots describing the distribution of mutational effect scores for each substitution are shown for three different structural contexts as determined using DSSP: α-helices (left panel, N = 8669), β-sheets (middle panel, N = 4796), and turns (right panel, N = 3329). (B) The mutational effect score distributions for each substitution in α-helices (left panel), β-sheets (middle panel), and turns (right panel) are shown. The vertical line in each panel represents the median effect score for all substitutions in that secondary structure type.