Table 4.
Cardiac Events (14.5‐Year) by SD and Quartiles of hsTnI Adjusted for Framingham Risk Factors With Lipids
| No. of Events (%) | Adjusted HR (95% CI) | P Value | |
|---|---|---|---|
| Coronary heart disease events | |||
| Per SD of LN‐hsTnI | 164/774 | 1.34 (1.14–1.56) | <0.001 |
| Q1 hsTnI (<3.6 ng/L) | 18/180 (10.0) | 1 (reference) | |
| Q2 hsTnI (3.6–4.4 ng/L) | 34/199 (17.1) | 1.50 (0.82–2.72) | 0.186 |
| Q3 hsTnI (4.5–5.7 ng/L) | 48/193 (24.9) | 2.33 (1.32–4.13) | 0.004 |
| Q4 hsTnI (≥5.8 ng/L) | 64/202 (31.7) | 2.84 (1.62–4.99) | <0.001 |
| Hard CHD eventsa | |||
| Per SD of LN‐hsTnI | 108/774 | 1.48 (1.23–1.80) | <0.001 |
| Q1 hsTnI (<3.6 ng/L) | 10/180 (5.6) | 1 (reference) | |
| Q2 hsTnI (3.6–4.4 ng/L) | 24/199 (12.1) | 2.37 (1.10–5.13) | 0.028 |
| Q3 hsTnI (4.5–5.7 ng/L) | 27/193 (14.0) | 2.47 (1.14–5.35) | 0.022 |
| Q4 hsTnI (≥5.8 ng/L) | 47/202 (23.3) | 4.10 (1.95–8.62) | <0.001 |
| Heart failure events | |||
| Per SD of LN‐hsTnI | 78/774 | 1.55 (1.24–1.93) | <0.001 |
| Q1 hsTnI (<3.6 ng/L) | 12/180 (6.7) | 1 (reference) | |
| Q2 hsTnI (3.6–4.4 ng/L) | 11/199 (5.5) | 0.78 (0.32–1.88) | 0.577 |
| Q3 hsTnI (4.5–5.7 ng/L) | 14/193 (7.3) | 1.20 (0.52–2.74) | 0.667 |
| Q4 hsTnI (≥5.8 ng/L) | 41/202 (20.3) | 3.39 (1.66–6.91) | 0.001 |
Cox regression models were adjusted for Framingham risk factors with lipids plus treatment code. CHD indicates coronary heart disease; HR, hazard ratio; hsTnI, high‐sensitivity cardiac troponin I.
a
Hard CHD is defined as myocardial infarction hospitalization or coronary heart disease death.