Table 3.
Modeling Analysis of Pancreatic β‐Cell Function From OGT Data
| Control (n=21) | HF (n=140) | P Value | HF With Adverse Events | HF With No Adverse Events | P Value | |
|---|---|---|---|---|---|---|
| Basal insulin secretion, pmol·min−1·m−2 | 113±34 | 194±86 | <0.0001 | 208±90 | 184±81 | 0.1 |
| Total insulin secretion, nmol·m−2 | 55±18 | 91±28 | <0.0001 | 94±31 | 91±27 | 0.5 |
| Glucose sensitivity, pmol·min−1·m−2·mM−1 | 189±98 | 151±81 | 0.1 | 154±80 | 149±81 | 0.8 |
| Rate sensitivity, pmol·m−2·mM−1 | 2217±3047 | 1046±1376 | 0.1 | 1287±1434 | 896±1320 | 0.1 |
| Potentiation factor ratio | 1.8±1.6 | 1.3±0.5 | 0.1 | 1.3±0.4 | 1.3±0.5 | 0.8 |
For explanation of parameters, see Methods. Adverse event during follow‐up: death, urgent transplantation, or implantation of a ventricular assist device. HR indicates heart failure; OGT, oral glucose tolerance test.