Skip to main content
. 2017 Aug 2;6(8):e005495. doi: 10.1161/JAHA.117.005495

Figure 7.

Figure 7

Transient receptor potential melastatin subtype 8 (TRPM8) activation by dietary menthol attenuates vascular dysfunction in Angiotensin II (Ang II)–induced hypertensive mice. A and B, Dietary menthol (0.5%) for 2 weeks before Ang II infusion (0.7 mg/kg per day) partially normalized systolic blood pressure in wild‐type (WT) but not Trpm8−/− mice. n=6 for Saline‐normal diet (ND) group, and n=8 for Ang II groups. C and D, Dietary menthol ameliorated mesenteric artery constriction in Ang II–treated WT mice but not Trpm8−/− mice. Preincubation of mitoTEMPO (Mito T, 50 μmol/L) for 2 hours blunted the enhanced vasoconstriction from Ang II–induced hypertensive mice. n=6. *P<0.05 vs saline‐ND; # P<0.05 vs Ang II‐ND; && P<0.01 vs baseline (0 day) using repeated‐measures ANOVA. Data are expressed as mean±SEM. Men indicates ND plus menthol supplementation (0.5%).