Table 3.
Significant Predictors of SCD and Non‐SCD Cardiovascular Mortality in All Women (N=886)
| Predictors | Non‐SCD (21 Events) | SCD (27 Events) | P of Non‐SCD vs SCDb |
|---|---|---|---|
| HR (95% CI)a | HR (95% CI)a | ||
| Age, y | 1.11 (1.06–1.17)c | 1.05 (1.01–1.09)d | 0.032 |
| White race | 0.44 (0.17–1.14) | 0.38 (0.17–0.85)d | >0.99 |
| Obstructive CAD | 4.43 (1.43–13.70)e | 2.84 (1.23–6.52)d | 0.53 |
| CAD severity score (log) | 2.67 (1.50–4.73)c | 2.41 (1.51–3.84)c | >0.99 |
| Left ventricular ejection fraction | 0.95 (0.92–0.98)e | 0.96 (0.93–0.98)e | >0.99 |
| Number of CAD risk factorsf | 1.48 (1.11–1.96) e | 1.52 (1.18–1.96) e | >0.99 |
| Prior MI or revascularization | 5.02 (1.91–13.21) c | 1.97 (0.91–4.26) | 0.09 |
| History of Revascularization | 2.82 (1.18–6.78)d | 2.25 (1.00–5.06)d | >0.99 |
| QTc, per 10 ms | 1.08 (0.93–1.25) | 1.19 (1.07–1.32)e | 0.23 |
| Systolic blood pressure, mm Hg | 1.02 (1.005–1.04)d | 1.02 (0.999–1.03) | 0.74 |
| Diastolic blood pressure, mm Hg | 1.06 (1.02–1.10)e | 0.99 (0.96–1.03) | 0.013 |
| Ever smoking | 1.38 (0.58–3.28) | 3.08 (1.29–7.32)e | 0.14 |
| Diabetes mellitus | 2.15 (0.90–5.13) | 2.59 (1.21–5.55)d | >0.99 |
| Metabolic syndrome | 1.16 (0.46–2.93) | 3.91 (1.57–9.75)e | 0.042 |
| Duke Activity Score Index | 0.91 (0.86–0.97)e | 0.99 (0.96–1.02) | 0.011 |
| COPD | 5.00 (1.67–16.98)e | 2.64 (0.79–8.76) | 0.39 |
| Estimated GFR, mL/min/1.73 m2 | 0.97 (0.95–0.99)e | 1.003 (0.99–1.02) | 0.005 |
| History of depression | 1.46 (0.52–4.05) | 2.63 (1.21–5.72)d | 0.29 |
| Hemoglobin | 0.70 (0.52–0.95)d | 1.04 (0.76–1.42) | 0.047 |
Not tabulated: moderate predictors (defined as P>0.01 but <0.05 and not differing significantly between outcomes) of non‐SCD were history of hypertension, history of peripheral vascular disease, log IL6, and resting heart rate. Log SAA, use of antidepressants, diuretics and nitrates were moderately predictive of SCD. Variables not predicting either outcome included postmenopausal status, history of oral contraceptive or hormone therapy use, body mass index, lipids, homeostasis model assessment, and use at baseline of digitalis, statins, beta blockers, or hormone therapy. CAD indicates coronary artery disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; HR, hazard ratio; IL6, Interleukin 6; MI, myocardial infarction; QTc, corrected QT interval; SAA, Serum Amyloid A; SCD, sudden cardiac death.
Except for age, all P values are age‐adjusted.
P value when comparing the predictors across different outcomes. A P value <0.05 suggests a variable to be a unique predictor.
P≤0.001.
P≤0.05.
P≤0.01.
Includes diabetes mellitus, history of dyslipidemia, history of hypertension, family history of CAD, body mass index ≥40, history of smoking, and prior MI or revascularization.