Table 11.
RRs and Their 95% CIs for Childhood MetS Predicting the Risk for High cIMT (≥90th Percentile) in Adulthood
| Age at Childhood Measurement in Years (No. of High Intima‐Media Thickness Events in Adulthood/No. of Subjects) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 to 4 (N=32/369) | 5 to 7 (N=47/550) | 8 to 10 (N=45/609) | 11 to 13 (N=67/824) | 14 to 16 (N=69/779) | 17 to 18 (N=62/576) | |||||||
| RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | |
| MetSNCEP75 (yes/no) | 1.53 (0.65–3.59) | 0.32 | 1.57 (0.92–2.68) | 0.10 | 1.33 (0.83–2.11) | 0.22 | 2.01 (1.36–2.96) | 0.0004 | 2.50 (1.75–3.57) | <0.0001 | 2.18 (1.48–3.22) | <0.0001 |
| MetSPed (yes/no)a | ··· | ··· | 0.86 (0.31–2.34) | 0.76 | 1.31 (0.72–2.37) | 0.38 | 2.29 (1.51–3.47) | <0.0001 | 2.22 (1.50–3.29) | <0.0001 | 2.19 (1.24–3.52) | <0.0001 |
| MetSCook (yes/no) | 1.05 (0.24–4.71) | 0.95 | 2.19 (0.61–7.78) | 0.22 | 1.97 (0.86–4.52) | 0.11 | 3.99 (2.11–7.54) | <0.0001 | 5.73 (3.31–9.90) | <0.0001 | 4.11 (2.19–7.72) | <0.0001 |
All models are adjusted for sex, study cohort, and year. CI indicates 95% confidence interval; cIMT, carotid intima‐media thickness; MetS, metabolic syndrome; RR, risk ratio.
a
MetSPed was defined only for subjects aged 6 to 18 years.