Table 6.
Cox Proportional Hazard Models Stratifying on the Matched Pairs for 1‐Year Recurrent Cardiovascular Events (Followed From Index Date for Dose Change)
| Number of Events (%) | HR (95%CI) | P Value | |
|---|---|---|---|
| Statin‐maintained vs statin‐discontinued, N=16 706 | |||
| Recurrent stroke | |||
| Statin‐maintained | 284 (3.4) | 1.00 (reference) | |
| Statin‐discontinued | 387 (4.6) | 1.38 (1.18‐1.60) | <0.0001 |
| Ischemic stroke | |||
| Statin‐maintained | 255 (3.1) | 1.00 (reference) | |
| Statin‐discontinued | 349 (4.2) | 1.38 (1.18‐1.62) | <0.0001 |
| Intracerebral hemorrhage | |||
| Statin‐maintained | 27 (0.3) | 1.00 (reference) | |
| Statin‐discontinued | 36 (0.4) | 1.35 (0.82‐2.22) | 0.24 |
| Myocardial infarction | |||
| Statin‐maintained | 22 (0.3) | 1.00 (reference) | |
| Statin‐discontinued | 27 (0.3) | 1.23 (0.70‐2.16) | 0.47 |
| All‐cause mortality | |||
| Statin‐maintained | 56 (0.7) | 1.00 (reference) | |
| Statin‐discontinued | 76 (0.9) | 1.39 (0.98‐1.96) | 0.07 |
| All major eventsa | |||
| Statin‐maintained | 349 (4.2) | 1.00 (reference) | |
| Statin‐discontinued | 476 (5.7) | 1.38 (1.20‐1.58) | <0.0001 |
| Stenting and endarterectomy | |||
| Statin‐maintained | 20 (0.2) | 1.00 (reference) | |
| Statin‐discontinued | 19 (0.2) | 0.95 (0.51‐1.78) | 0.88 |
| Any hospitalization | |||
| Statin‐maintained | 1099 (13.2) | 1.00 (reference) | |
| Statin‐discontinued | 1256 (15.0) | 1.16 (1.07‐1.26) | 0.0003 |
| Statin‐maintained vs statin‐reduced, N=6350 | |||
| Recurrent stroke | |||
| Statin‐maintained | 128 (4.0) | 1.00 (reference) | |
| Statin‐reduced | 107 (3.4) | 0.84 (0.65‐1.08) | 0.17 |
| Ischemic stroke | |||
| Statin‐maintained | 114 (3.6) | 1.00 (reference) | |
| Statin‐reduced | 99 (3.1) | 0.87 (0.66‐1.14) | 0.30 |
| Intracerebral hemorrhage | |||
| Statin‐maintained | 14 (0.4) | 1.00 (reference) | |
| Statin‐reduced | 8 (0.3) | 0.57 (0.24‐1.36) | 0.21 |
| Myocardial infarction | |||
| Statin‐maintained | 12 (0.4) | 1.00 (reference) | |
| Statin‐reduced | 13 (0.4) | 1.08 (0.50‐2.38) | 0.84 |
| All‐cause mortality | |||
| Statin‐maintained | 25 (0.8) | 1.00 (reference) | |
| Statin‐reduced | 22 (0.7) | 0.88 (0.50‐1.56) | 0.67 |
| All major eventsa | |||
| Statin‐maintained | 162 (5.1) | 1.00 (reference) | |
| Statin‐reduced | 138 (4.4) | 0.85 (0.68‐1.07) | 0.16 |
| Stenting and endarterectomy | |||
| Statin‐maintained | 14 (0.4) | 1.00 (reference) | |
| Statin‐reduced | 1 (0.03) | 0.07 (0.01‐0.54) | 0.01 |
| Any hospitalization | |||
| Statin‐maintained | 349 (11.0) | 1.00 (reference) | |
| Statin‐reduced | 322 (10.1) | 0.92 (0.79‐1.07) | 0.30 |
Propensity score matching was computed from age, sex, stroke severity index, hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke history, heart failure, chronic kidney disease, chronic obstructive pulmonary disease, peripheral vascular disease, and sleep apnea. HR indicates hazard ratio.
a
All major events: composite of stroke, acute myocardial infarction, and death.