Table 3.
Baseline 12‐Lead ECG Ectopy and Overall Mortality
| Adjustment | CHS | ARIC | ||||||
|---|---|---|---|---|---|---|---|---|
| Point Estimate | 95% CI | P Value | Point Estimate | 95% CI | P Value | |||
| A 12‐lead PAC as a predictor of mortality | ||||||||
| None | HR | 1.6 | 1.4 to 1.9 | <0.001 | HR | 1.8 | 1.5 to 2.1 | <0.001 |
| a | HR | 1.3 | 1.1 to 1.5 | 0.008 | HR | 1.4 | 1.2 to 1.7 | <0.001 |
| Plusa interim AF | HR | 1.2 | 1.0 to 1.4 | 0.08 | HR | 1.2 | 1.0 to 1.5 | 0.06 |
| % mediated by AF | 35% | −0.2% to 124% | 42% | 16% to 111% | ||||
| A 12‐lead PVC as a predictor of mortality | ||||||||
| None | HR | 1.5 | 1.3 to 1.7 | <0.001 | HR | 2.3 | 1.9 to 2.7 | <0.001 |
| b | HR | 1.2 | 1.0 to 1.3 | 0.044 | HR | 1.7 | 1.4 to 2.0 | <0.001 |
| Plusb interim HF | HR | 1.1 | 0.9 to 1.2 | 0.42 | HR | 1.5 | 1.3 to 1.8 | <0.001 |
| % mediated by HF | 60% | −5% to 709% | 22% | 0% to 45% | ||||
White shaded areas include results regarding ectopy as a predictor of mortality. Gray shaded areas include mediation results (specifically how much the PAC‐mortality relationship is attenuated and therefore statistically explained by interim atrial fibrillation and how much the PVC‐mortality relationship is attenuated and therefore statistically explained by interim heart failure). AF indicates atrial fibrillation; ARIC, Atherosclerosis Risk in Communities; CHS, Cardiovascular Health Study; HF, heart failure; HR, hazard ratio; PAC, premature atrial contraction; PVC, premature ventricular contraction.
Adjusted for age, sex, race, study site, hypertension, diabetes mellitus, myocardial infarction, coronary artery disease, heart failure, and study site.
Adjusted for age, sex, race, study site, hypertension, diabetes mellitus, myocardial infarction, coronary artery disease, beta‐blocker, atrial fibrillation, and study site (in CHS, also adjusted for baseline left ventricular ejection fraction).