Table 4.
Analysis of Genotypic Association of SNPs in FGF12B Under 3 Genetic Models
| SNP | Model | Without Adjustment | With Adjustment | ||
|---|---|---|---|---|---|
| P obs | OR (95% CI) | P adj | OR (95% CI) | ||
| rs2686464, Discovery sample | Dominant (C) | 0.073 | 2.36 (0.90–6.18) | 0.082 | 2.47 (0.89–6.84) |
| Recessive (C) | 0.682 | 0.92 (0.60–1.40) | 0.848 | 1.05 (0.66–1.65) | |
| Additive (C) | 0.122 | ··· | 0.392 | 1.18 (0.81–1.71) | |
| rs4687326, Discovery sample | Dominant (T) | 0.364 | 1.19 (0.82–1.73) | 0.224 | 1.28 (0.86–1.89) |
| Recessive (T) | 0.447 | 0.72 (0.30–1.69) | 0.606 | 0.79 (0.33–1.91) | |
| Additive (T) | 0.377 | ··· | 0.414 | 1.14 (0.83–1.58) | |
| rs1460922, Discovery sample | Dominant (G) | 0.018 | 1.68 (1.09–2.58) | 0.042 | 1.60 (1.02–2.51) |
| Recessive (G) | 0.017 | 3.18 (1.17–8.64) | 0.030 | 3.17 (1.12–9.01) | |
| Additive (G) | 0.011 | ··· | 0.010 | 1.64 (1.12–2.39) | |
| rs1460922, Replication sample | Dominant (G) | 0.190 | 1.33 (0.87–2.03) | 0.104 | 1.53 (0.92–2.56) |
| Recessive (G) | 0.007 | 3.23 (1.32–7.90) | 0.008 | 4.60 (1.48–14.29) | |
| Additive (G) | 0.024 | ··· | 0.017 | 1.67 (1.10–2.56) | |
| rs1460922, Combined sample | Dominant (G) | 4.00E‐03 | 1.55 (1.15–2.08) | 4.00E‐03 | 1.59 (1.12–2.17) |
| Recessive (G) | 3.70E‐04 | 3.16 (1.63–6.14) | 1.00E‐03 | 3.31 (1.65–6.64) | |
| Additive (G) | 2.79E‐04 | ··· | 1.79E‐04 | 1.64 (1.27–2.12) | |
CI indicates confidential interval; OR, odds ratio; P adj, P value for association after adjusting for covariates of sex and age by multiple logistic regression analysis using SPSS version 17.0; P obs, P value for association before adjusting for covariates of age and sex by 2×2 contingence tables using PLINK version 1.07.