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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: Sci Immunol. 2016 Dec 16;1(6):eaah6109. doi: 10.1126/sciimmunol.aah6109

Fig. 5. Distribution of immunoglobulin heavy chain isotypes, somatic hypermutation and antigen-driven selection in peripheral blood B cells of patients with RAG deficiency.

Fig. 5

Frequency of immunoglobulin heavy chain constant gene usage among unique IGH sequences from peripheral blood lymphocytes of RAG-deficient patients and healthy controls (A and B). In panel B, mean values ± SE are shown (one-tail, unpaired t-test). Contribution of the most abundant clonotype to the total number of IGH sequences in patients and controls (C). Distribution of various isotypes among the most abundant IGH transcript (D). Rate of somatic hypermutation (SHM) in IGH transcripts (E, mean ± SE; unpaired t-test). Frequency of unique IGH transcripts displaying evidence of antigen-mediated selection based on the distribution of replacement and silent mutations (F). Rate of SHM and antigen mediated selection in IGHV3-9 for patients with CID-G/AI and healthy controls with line at the mean (G).