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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: J Addict Med. 2016 Jul-Aug;10(4):274–279. doi: 10.1097/ADM.0000000000000229

Figure 1. Effects of Sativex and Motivational Enhancement Therapy / Cognitive Behavioral Therapy (MET/CBT) intervention on cannabis dependence.

Figure 1

Columns represent average values (+SEM) for the four participants completing treatment and follow-up phases: a) cannabis intake (g) per week as reported on the timeline followback (TLFB), b) Sativex self-titration (sprays/week) as reported in the smoking diary, c) craving for cannabis was determined using the Cannabis Craving Questionnaire (CCQ), d) cannabis withdrawal was measured using the Cannabis Withdrawal Checklist (CWC). Cannabinoids of interest in urine were quantified using a two-dimensional gas chromatography-mass spectrometry method (2D-GCMS), e) creatinine-normalized urine ∆9-tetrahydrocannabinol (THC) concentrations, f) creatinine-normalized urine cannabidiol (CBD) concentrations. * (p<0.05), ** (p<0.01) vs baseline. Repeated measures ANOVA followed by pairwise comparisons.