Table 3.
Histologic Changes in Immunodeficient Mice Experimentally Infected with MNV.a
| Reference | Mouse Strain | MNV Strain | Liver | Lung | MLN | Peritoneum | Small Intestine | Large Intestine | Brain | Spleen | Stomach |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | Stat1−/− | MNV-1 | + | + | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 22 | Rag2−/−/Stat1−/− | MNV-1 | + | + | n/r | n/r | n/r | n/r | + | n/r | n/r |
| 22 | IFNαβγR−/− | MNV-1 | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r | n/r |
| 31 | 129S6/SvEv-Stat1tm1Rds | MNV-1 (cDNA derived) | + | n/r | n/r | n/r | + | n/r | n/r | + | n/r |
| 31 | 129S6/SvEv-Stat1tm1Rds | MNV-1 VF1 (ORF4) deficient | + | n/r | n/r | n/r | − | n/r | n/r | + | n/r |
| 33 | 129S6/SvEv-Stat1tm1Rds | MNV-1.CW3 | − | + | n/r | n/r | + | n/r | n/r | + | n/r |
| 42 | AG129 (IFNαβγR−/−) | MNV-1.CW3 | n/r | n/r | n/r | n/r | + | n/r | n/r | n/r | n/r |
| 45 | 129S6/SvEv-Stat1tm1Rds | MNV-07 | + | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 45 | 129S6/SvEv-Stat1tm1Rds | MNV-1.CW3 | + | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 46 | C57BL/6-Stat1tm1Dlv | pCW3 (MNV-1) | + | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 46 | C57BL/6-Stat1tm1Dlv | pCW3 PCR6 | + | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 46 | C57BL/6-Stat1tm1Dlv | pCR6 | − | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| 46 | C57BL/6-Stat1tm1Dlv | pCR6 PCW3 | + | n/r | n/r | n/r | n/r | n/r | n/r | + | n/r |
| Unpublished | Tlr4−/− | MNV-4 | n/r | n/r | − | n/r | n/r | − | n/r | n/r | n/r |
| Unpublished | Tlr4−/− + Klebsiella and Proteus | MNV-4 | n/r | n/r | − | n/r | n/r | − | n/r | n/r | n/r |
a
+ = histologic changes reported, − = no histologic changes, n/r = not reported, MLN= mesenteric lymph node