Table 6.
Localization of MNV by immunohistochemistry, immunofluorescence, in situ hybridization, or in situ RT-PCR.a
| Reference | Mouse Strain | MNV Strain | Test Performed | Liver | Lung | MLN | Peritoneum | Small Intestine | Spleen | Aorta |
|---|---|---|---|---|---|---|---|---|---|---|
| 3 | B6.129P2-Il10tm1Cgn/JZtm | MNV/Hannover1/2007/DEU | in situ RT-PCR | n/r | n/r | n/r | n/r | + | n/r | n/r |
| 4 | Atg16L1HM | MNV CR6 | immunohistochemistry | n/r | n/r | n/r | n/r | − | n/r | n/r |
| 12 | B6.129P2-Apoetm1Unc/J | MNV-4 | in situ hybridization | n/r | n/r | n/r | n/r | n/r | n/r | + |
| 33 | 129S6/SvEvTac | MNV-1.CW3 | immunofluorescence | n/r | n/r | n/r | n/r | + | n/r | n/r |
| 33 | 129S6/SvEv-Stat1tm1Rds | MNV-1.CW3 | immunofluorescence | n/r | n/r | n/r | n/r | + | n/r | n/r |
| 38 | Tac:SW | endemic | immunohistochemistry | + | n/r | + | n/r | n/r | n/r | n/r |
| 47 | Rag−/−/γc−/− | MNV-1.CW3 | immunohistochemistry | + | n/r | n/r | n/r | n/r | + | n/r |
| 49 | Rag1−/−/IFNγR−/− | endemic | immunohistochemistry | + | + | + | + | + | n/r | n/r |
| 49 | OT1Rag1−/−/IFNγR−/− | endemic | immunohistochemistry | + | + | n/r | − | − | + | n/r |
| 49 | OT2Rag1−/−/IFNγR−/− | endemic | immunohistochemistry | + | + | n/r | n/r | − | n/r | n/r |
| 49 | Rag1−/−/Stat1−/− | endemic | immunohistochemistry | + | + | + | + | + | n/r | n/r |
| 49 | Rag2−/− | endemic | immunohistochemistry | − | − | + | − | − | n/r | n/r |
| 50 | 129S6/SvEv-Stat1tm1Rds | MNV-1 | immunohistochemistry | + | n/r | n/r | n/r | n/r | + | n/r |
a
+ = MNV antigen detected, − = MNV antigen not detected, n/r = not reported, MLN= mesenteric lymph node