Table 3.
Discriminating test characteristics of all frailty measurements used in the Geriatric Assessment in Older Patients Starting Dialysis Study and the prevalence of frailty according the tests
| Screening Modality | Cutoff Value | Prevalence of Frailty, % | Sensitivity, % | Specificity, % | PPV, % | NPV, % |
|---|---|---|---|---|---|---|
| Fried Frailty Index | ≥3 | 48 | 59 (48–70) | 85 (66–96) | 92 (83–97) | 41 (34–49) |
| Groningen Frailty Indicator | ≥4 | 67 | 74 (64–83) | 52 (33–70) | 82 (76–87) | 40 (29–52) |
| G8 | ≤14 | 88 | 92 (85–97) | 26 (12–45) | 79 (75–82) | 53 (31–74) |
| ISAR-HP | ≥2 | 60 | 72 (61–81) | 79 (59–92) | 91 (83–96) | 48 (38–58) |
| VMS vulnerable elderly | ≥2 | 82 | 90 (79–96) | 38 (19–59) | 78 (72–83) | 60 (37–79) |
| Frailty question | ≥5 | 63 | 72 (61–82) | 67 (45–84) | 88 (80–93) | 42 (32–53) |
PPV, positive predictive value; NPV, negative predictive value; G8, Geriatric8; ISAR-HP, Identification of Seniors at Risk-Hospitalized Patients; VMS, Veiligheidsmanagementsysteem (Hospital Safety Program criteria); frailty question, clinical judgment of the nephrologist.