. 2013 Nov 11;23(1):45–52. doi: 10.1159/000355900

Table 2.

Scores of the small intestine of rats on days 2, 4 and 6 following treatment with MTX alone or MTX plus HES

Parameter	Control group (n = 19)	HES group (n = 19)	MTX group (n = 19)	MTX plus HES group (n = 21)
Day 2
Villus damage	0.33 ± 0.52	0.17 ± 0.41	1.17 ± 0.41^a	0.83 ± 0.41
Crypt damage	0.17 ± 0.41	0.00 ± 0.00	0.5 ± 0.84	0.83 ± 0.98
Cellular infiltration	0.00 ± 0.00	0.67 ± 0.52	1.33 ± 0.52^a	1.33 ± 0.52^a
Goblet cell depletion	0.00 ± 0.00	0.00 ± 0.00	0.50 ± 0.55	0.17 ± 0.41
Total small intestinal damage score	0.33 ± 0.52	0.83 ± 0.75	3.50 ± 1.98^a	3.17 ± 1.47^a
Day 4
Villus damage	0.17 ± 0.41	1.00 ± 0.00	2.17 ± 0.75^a	1.67 ± 0.52^a
Crypt damage	0.00 ± 0.00	1.00 ± 0.00	2.00 ± 0.89^a	1.00 ± 0.00^a ^b
Cellular infiltration	0.00 ± 0.00	2.00 ± 0.00	1.83 ± 0.41^a	1.50 ± 0.55^a
Goblet cell depletion	0.00 ± 0.00	0.00 ± 0.00	2.00 ± 0.63^a	2.00 ± 0.00^a
Total small intestinal damage score	0.17 ± 0.41	4.00 ± 0.00	8.00 ± 2.37^a	6.33 ± 0.82^a
Day 6
Villus damage	0.14 ± 0.38	0.57 ± 0.53	1.14 ± 0.69^a	0.56 ± 0.53
Crypt damage	0.00 ± 0.00	0.29 ± 0.49	0.14 ± 0.38	0.22 ± 0.44
Cellular infiltration	0.14 ± 0.38	1.00 ± 0.58	1.14 ± 0.38^a	1.11 ± 0.33^a
Goblet cell depletion	0.00 ± 0.00	0.00 ± 0.00	0.57 ± 0.53^a	0.11 ± 0.33
Total small intestinal damage score	0.29 ± 0.49	1.86 ± 1.22	3.00 ± 1.53^a	2.00 ± 0.87^a

Data are arithmetical means ± SD.

Statistically significant at p < 0.05 as compared to control group.

Statistically significant at p < 0.05 as compared to MTX group.