Table 1.
Clinical and steady-state laboratory parameters amongst adult males with homozygous SCD
| n | Mean (SD) | Median | Independent t test p value | Correlation coefficient (significance) | |
|---|---|---|---|---|---|
| Age (years) | |||||
| All patients | 123 | 24.9 (7.0) | 24 | ||
| Priapism | 28 | 26.8 (5.4) | 26 | 0.049* | −0.232 (0.010)* |
| No priapism | 95 | 24.3 (7.3) | 23 | ||
| Frequency of crises per annum | |||||
| All patients | 72 | 3 (4.8) | 2 | ||
| Priapism | 24 | 3 (3.2) | 3 | 0.271 | 0.116 (0.165) |
| No priapism | 48 | 4 (5.4) | 3 | ||
| Leucocyte count (×109/l) | |||||
| All patients | 115 | 13.1 (7.5) | 11.2 | ||
| Priapism | 27 | 10.5 (4.5) | 8.9 | 0.008* | 0.234 (0.012)* |
| No priapism | 88 | 13.9 (8.0) | 11.7 | ||
| Platelet count (×109/l) | |||||
| All patients | 104 | 346 (150) | 323 | ||
| Priapism | 25 | 323 (141) | 302 | 0.359 | 0.112 (0.257) |
| No priapism | 79 | 354 (152) | 347 | ||
| Hb concentration (g/dl) | |||||
| All patients | 99 | 7.8 (1.7) | 7.8 | ||
| Priapism | 23 | 7.9 (1.6) | 7.7 | 0.683 | −0.006 (0.951) |
| No priapism | 76 | 7.8 (1.7) | 7.8 | ||
| Indirect bilirubin | |||||
| All patients | 67 | 15.2 (24.9) | 8.6 | ||
| Priapism | 17 | 11.3 (7.8) | 8.6 | 0.239 | −0.002 (0.981) |
| No priapism | 50 | 28.3 (28.2) | 8.6 | ||
| Direct bilirubin | |||||
| All patients | 68 | 26.7 (33.5) | 17.3 | ||
| Priapism | 17 | 22.2 (20.5) | 12.8 | 0.404 | 0.005 (0.966) |
| No priapism | 51 | 28.2 (36.9) | 17.5 | ||
| Serum AST | |||||
| All patients | 66 | 21.9 (19.2) | 17.0 | ||
| Priapism | 17 | 21.4 (17.3) | 15.0 | 0.877 | 0.28 (0.822) |
| No priapism | 49 | 22.1 (19.9) | 17.0 | ||
*
Significant at p< 0.05.