Table 5.

iPANDA signaling pathways activation analysis. Information about signaling pathways was obtained from various pathway databases.

	Frontal vs. Vertex scalp before treatment	Vertex scalp after and before treatment (responders)	Frontal scalp after and before treatment (responders)	Frontal vs. Vertex scalp after treatment (responders)
Upregulated pathways	IL-2, ILK, MAPK, TGF-β, JAK/STAT, PTEN, Akt	PTEN, Cellular apoptosis	Protein digestion and absorption (KEGG), Ras, mTOR, Wnt	Ras, IL-2, Protein digestion and absorption (KEGG), mTOR
Downregulated pathways	Presenilin action in Notch and Wnt signaling (NCI), IL-6	ILK, Akt, mTOR, JAK/STAT, MAPK, Ras	Akt, PTEN, MAPK, ILK	Akt, ILK, MAPK, PTEN