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. 2017 Jul 20;102(9):3600–3609. doi: 10.1210/jc.2017-01057

Table 2.

Spearman Correlations of Acute-Phase Proteins With Baseline Clinical and Metabolic Traits in Men Without Type 2 Diabetes in the METSIM Baseline Study

Baseline Study Variable GlycA, mmol/L
 IL-1RA, µg/L
 hs-CRP, mg/L
Men, n ρ P Value Men, n ρ P Value Men, n ρ P Value
Age, y 8716 0.022 0.040a 8748 −0.027 0.013a 8748 0.056 <0.0001b
BMI, kg/m2 8713 0.308 <0.0001b 8745 0.372c <0.0001b 8745 0.332 <0.0001b
Waist, cm 8712 0.334 <0.0001b 8744 0.387 <0.0001b 8744 0.365 <0.0001b
Fat mass, % 8694 0.243 <0.0001b 8726 0.279 <0.0001b 8726 0.300 <0.0001b
Systolic BP, mm Hg 8716 0.177c <0.0001b 8748 0.049 <0.0001b 8748 0.114 <0.0001b
Diastolic BP, mm Hg 8716 0.197c <0.0001b 8748 0.117 <0.0001b 8748 0.136 <0.0001b
LDL cholesterol, mmol/L 8716 0.169c <0.0001b 8745 −0.019 0.078 8745 0.108 <0.0001b
HDL cholesterol, mmol/L 8716 −0.344c <0.0001b 8746 −0.268 <0.0001b 8746 −0.178 <0.0001b
TAG, mmol/L 8716 0.601c <0.0001b 8748 0.240 <0.0001b 8748 0.171 <0.0001b
ApoA1, g/L 8716 −0.063 <0.0001b 8746 −0.133c <0.0001b 8746 −0.095 <0.0001b
ApoB, g/L 8716 0.416c <0.0001b 8746 0.120 <0.0001b 8746 0.185 <0.0001b
Adiponectin, μg/mL 8714 −0.169 <0.0001b 8746 −0.145 <0.0001b 8746 −0.101 <0.0001b
ALT, U/L 8716 0.163 <0.0001b 8748 0.249c <0.0001b 8748 0.123 <0.0001b
FPG, mmol/L 8716 0.132 <0.0001b 8748 0.168c <0.0001b 8748 0.060 <0.0001b
2hPG, mmol/L 8716 0.212 <0.0001b 8748 0.210 <0.0001b 8748 0.138 <0.0001b
Glucose AUC, mmol/L × min 8686 0.230 <0.0001b 8718 0.229 <0.0001b 8718 0.137 <0.0001b
InsAUC0–30/GluAUC0–30 8670 0.302c <0.0001b 8702 0.243c <0.0001b 8702 0.156c <0.0001b
Matsuda ISI 8664 −0.409c <0.0001b 8696 −0.353 <0.0001b 8696 −0.224 <0.0001b
Disposition indexd 8664 −0.177 <0.0001b 8696 −0.185 <0.0001b 8696 −0.119 <0.0001b

Abbreviations: ALT, alanine aminotransferase; ρ, Spearman correlation coefficient.

a

P < 0.05 was considered to indicate nominal statistical significance.

b

Bonferroni-adjusted P < 0.00088 was considered to indicate statistical significance (0.05/19 traits × 3 acute-phase proteins).

c

Correlation coefficient was significantly (P < 0.05) different from correlation coefficients of other two acute-phase proteins with the same traits using Fisher r-to-z transformation.

d

Disposition index was calculated as Matsuda ISI × InsAUC0–30/GluAUC0–30.