Figure 2.

Impact of acute oral androgen challenge (DHEA 100 mg) on in vivo metabolic markers in serum and adipose tissue microdialysate. Serum glucose, insulin, and free fatty acids (a–c) and intra-adipose pyruvate, glucose, lactate, and glycerol levels (d–g) in PCOS (n = 10, dark line, ●) and control women (n = 10, dotted line, ○ across the DHEA challenge test) (mean ± standard error of the mean). Time of oral administration of 100 mg DHEA indicated by arrow. (h) AUC for glycerol between 120 and 240 minutes after androgen exposure in the PCOS group compared with controls. *P < 0.05 (Mann-Whitney U test). For further details see Supplemental Methods ^{(141KB, docx)} .