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. 2017 Jun 22;102(9):3327–3339. doi: 10.1210/jc.2017-00947

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 5. — Expression, activity, and inhibition of the androgen-activating enzyme AKR1C3 in subcutaneous adipose tissue. (a–d) Expression and activity of AKR1C3 with and without insulin stimulation in the human preadipocyte SGBS cell line and primary subcutaneous adipocytes from women undergoing elective surgery. (e) Effect of pharmacologic AKR1C3 inhibition by 3-4-trifluoromethyl-phenylamino-benzoic acid (10 μM) for 24 hours (gray bars) on adipose androgen generation, assessed as conversion of A4 to testosterone. (f) Impact of pharmacologic AKR1C3 inhibition on A4-mediated de novo lipogenesis. All data are presented as the mean ± standard error of the mean of 3 to 5 experiments. Significance levels: *P < 0.05; **P < 0.01; ***P < 0.001 (analysis of variance with Tukey post hoc test).