Figure 2.

Diverse islet profiles in the pancreas of CHI-A tissues. (a) Within regions that have a normal active appearance, (b) islets are enriched with insulin-expressing β-cells and (c) have fewer somatostatin-expressing δ-cells. However, within domains that are quiescent, (a) islets have condensed cytoplasm, leading to the appearance of nuclear crowding, (b) fewer β-cells, and (c) a higher number of δ-cells. Note that the distribution of β-cells in quiescent islets is also different and that the cells occupy a central location within the islets. (b) This expression profile was also mirrored when β-cells were identified for the expression of proinsulin (inserts). (b, c) Dotted lines have been added to clarify the islet structure. The data are representative of n = 3 CHI-A cases. Scale bar = 50 μm; inserts = 20 μm. H&E, hematoxylin and eosin.