Figure 3.

Islet hormone expression in active and quiescent domains of the pancreas of CHI-A tissues. (a) Islets with a normal (active) appearance are enriched with insulin-expressing cells and have lower numbers of somatostatin- and glucagon-expressing cells. (b) In contrast, in the quiescent islets, somatostatin is enriched and the number of β-cells is low. Note that there is no difference in the abundance of glucagon-expressing α-cells. The data are representative of n = 3 CHI-A cases. Scale bars = 50 μm.