Table 2.
Baseline Thyroid Function Tests in Humans Before and After Treatment With L-T3
| Test | Born to RTH-β Fathers | Born to RTH-β Mothers | P Value |
|---|---|---|---|
| Number of subjects | 4 | 4 | |
| Before treatment | |||
| T4, µg/dL | 9.7 ± 0.7 | 8.6 ± 1.3 | NS |
| T3, ng/dL | 131 ± 2 | 110 ± 7 | NS |
| rT3, ng/dL | 25.1 ± 2.7 | 24.7 ± 3.2 | NS |
| FT4I | 9.4 ± 0.4 | 9.7 ± 1.4 | NS |
| TSH, mU/L | 1.42 ± 0.16 | 1.62 ± 0.18 | NS |
| Peak stimulated TSH, mU/L | 13.2 ± 1.7 | 10.4 ± 0.8 | NS |
| PRL, ng/mL | 15.5 ± 1.4 | 11.4 ± 3.8 | NS |
| Peak stimulated PRL, ng/mL | 98 ± 25 | 61 ± 39 | NS |
| After treatment | |||
| T4, µg/dL | 7.3 ± 0.55 | 6.6 ± 0.61 | NS |
| T3, ng/dL | 252 ± 33 | 248 ± 24 | NS |
| rT3, ng/dL | 24.7 ± 1.7 | 20.0 ± 2.3 | NS |
| FT4I | 7.6 ± 0.12 | 7.3 ± 0.39 | NS |
| TSH, mU/L | 0.14 ± 0.04 | 0.26 ± 0.10 | NS |
| Peak stimulated TSH, mU/L | 1.58 ± 0.52 | 6.83 ± 0.98 | <0.003 |
| PRL, ng/mL | 20.1 ± 11.5 | 10.6 ± 3.5 | NS |
| Peak stimulated PRL, ng/mL | 72.5 ± 9.4 | 62.8 ± 15.4 | NS |
Peak stimulated TSH and PRL values are after administration of TRH.
Abbreviation: NS, not significant.