Table 3.
Thyroid Function Tests in WT Progeny Born to RTH-β Fathers (Controls) and RTH-β Mothers
| Groups |
Humans |
Mice |
||||
|---|---|---|---|---|---|---|
| Born to RTH-β Fathers | Born to RTH-β Mothers | P Value | Born to RTH-β Sires | Born to RTH-β Dams | P Value | |
| Number of subjects | 9 | 15 | 8 | 7 | ||
| Age | 35 ± 6 y | 46 ± 5 y | NS | 64 ± 1 d | 62 ± 1 d | NS |
| T4, µg/dL | 8.6 ± 0.3 | 8.3 ± 0.3 | NS | 5.2 ± 0.1 | 4.8 ± 0.2 | NS |
| T3, ng/dL | 150 ± 8 | 130 ± 9 | NS | 63 ± 6 | 54 ± 5 | NS |
| rT3, ng/dL | 15.7 ± 0.9 | 19.2 ± 1.1 | <0.05 | 23.5 ± 1.3 | 25.8 ± 2.7 | NS |
| rT3/T3 ratio | 0.11 ± 0.01 | 0.16 ± 0.01 | <0.03 | 0.36 ± 0.02 | 0.48 ± 0.02 | <0.01 |
| FT4I | 9.1 ± 0.3 | 8.6 ± 0.3 | NS | |||
| TSH, mU/L | 2.9 ± 0.8 | 1.7 ± 0.2 | NS | 18 ± 2 | 41 ± 10 | <0.01 |
Abbreviation: NS, not significant.