Table 5.

Association Between Change in VAT and SAT With Changes in Sex Hormone in Linear Regression Models (Standardized β-Coefficient and P Value)

Model	ΔDHEAS		ΔTestosterone		ΔEstradiol		ΔEstrone		ΔSHBG
	β	P Value	β	P Value	β	P Value	β	P Value	β	P Value
Men
ΔVAT/SAT (L2-L3)	−0.02163	0.753	−0.14717	0.034	0.01657	0.825	0.13482	0.056	0.03523	0.610
ΔVAT/SAT (L3-L4)	−0.08639	0.226	−0.07009	0.334	0.03595	0.639	0.03554	0.625	−0.01969	0.787
ΔVAT+ΔSAT
ΔVAT (L2-L3)	−0.02142	0.811	−0.35215	<0.001	−0.04845	0.628	0.08643	0.339	−0.13947	0.120
ΔSAT (L2-L3)	0.09122	0.278	−0.14255	0.075	0.01069	0.909	−0.13659	0.098	−0.12242	0.146
ΔVAT+ΔSAT
ΔVAT (L3-L4)	−0.05313	0.549	−0.18248	0.035	−0.02181	0.826	0.04406	0.627	−0.11545	0.194
ΔSAT (L3-L4)	0.06705	0.407	−0.28501	<0.001	−0.00641	0.944	−0.00280	0.973	−0.16024	0.049
Women
ΔVAT/SAT (L2-L3)	−0.05731	0.358	−0.03425	0.609	0.01335	0.841	0.07792	0.362	0.02295	0.708
ΔVAT/SAT (L3-L4)	−0.09030	0.153	0.05729	0.400	−0.04630	0.499	0.02323	0.795	−0.04707	0.451
ΔVAT+ΔSAT
ΔVAT (L2-L3)	−0.09284	0.240	−0.08180	0.338	0.09420	0.262	0.21859	0.045	−0.05128	0.504
ΔSAT (L2-L3)	−0.01829	0.817	−0.07418	0.382	−0.06505	0.441	−0.05249	0.636	−0.19472	0.012
ΔVAT+ΔSAT
ΔVAT (L3-L4)	−0.08976	0.233	0.07866	0.324	0.02963	0.710	0.14627	0.189	−0.07556	0.298
ΔSAT (L3-L4)	−0.00756	0.915	−0.14886	0.049	0.02798	0.708	0.02856	0.775	−0.10776	0.116

Models enter both VAT and SAT simultaneously as a ratio or as separate independent variables. β-coefficients are in SD of changes (Δ) in sex hormones per SD increase in the change of adipose tissue depot, in cm² (Δcm²). Models adjust for age, race/ethnicity, randomization assignment, and size of adipose tissue measure at baseline. Boldface indicates P < 0.05.