Table 3.
HRs of the Clinicopathological Characteristics for PTC-Associated Patient Mortality in Multivariate Cox Proportional Hazards Analysis
| Characteristics |
All Variants |
CPTC |
FVPTC |
TCPTC |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Mortality in all PTC | ||||||||
| Age at diagnosis | 1.09 (1.07–1.11) | <0.001 | 1.10 (1.07–1.13) | <0.001 | 1.11 (1.00–1.24) | 0.060 | 1.01 (0.95–1.06) | 0.830 |
| Sex (male) | 1.53 (0.89–2.64) | 0.128 | 2.30 (1.19–4.45) | 0.014 | 0.21 (0.02–2.58) | 0.221 | 4.91 (0.67–36.15) | 0.119 |
| Tumor size | 1.23 (1.14–1.40) | <0.001 | 1.14 (0.96–1.36) | 0.137 | 1.08 (0.55–2.13) | 0.830 | 2.10 (1.38–3.20) | <0.001 |
| Extrathyroidal extension | 2.73 (1.43–5.22) | 0.002 | 3.44 (1.58–7.51) | 0.002 | 2.67 (0.23–31.03) | 0.433 | 0.23 (0.03–1.97) | 0.181 |
| Lymph node metastasis | 6.06 (2.96–12.38) | <0.001 | 5.22 (2.30–11.83) | <0.001 | —a | 0.932 | 13.91 (1.00–194.30) | 0.050 |
| Multifocality | 0.88 (0.49–1.56) | 0.653 | 0.69 (0.34–1.43) | 0.317 | 0.74 (0.10–5.76) | 0.772 | 0.46 (0.08–2.61) | 0.381 |
| Mortality in intrathyroidal PTC | ||||||||
| Age at diagnosis | 1.07 (0.98–1.17) | 0.151 | 4.80 (0.18–125.26) | 0.346 | —b | —b | 1.28 (0.02–111.60) | 0.915 |
| Sex (male) | 5.05 (0.42–60.89) | 0.202 | —a | 0.904 | —b | —b | —a | 0.918 |
| Tumor size | 1.40 (0.86–2.28) | 0.172 | 5.33 (0.06–512.24) | 0.473 | —b | —b | —a | 0.843 |
| Multifocality | —a | 0.976 | —a | 0.756 | —b | —b | —a | 0.940 |
For each clinicopathological risk factor, multivariate adjustment was performed to adjust the effects of the remaining factors indicated in the same section group.
a
Because of the low death number, HR could not be calculated.
b
HR and P value could not be calculated because of the zero death in unifocal and multifocal FVPTC in the intrathyroidal cohort.