Table 4.
The associations (adjusted OR and 95% CI) of migraine diagnosis and medication with acute coronary heart syndrome sub types
| Migraine measures | Angina (n=20,521)
|
Acute myocardial infarction* (n=77,278)
|
||
|---|---|---|---|---|
| Crude OR 95% CI | Adjusted OR 95% CI | Crude OR 95% CI | Adjusted OR 95% CI | |
| Migraine diagnosis | 2.75 (1.86–4.16) | 2.25 (1.48–3.48) | 1.56 (1.22–2.01) | 1.32 (1.02–1.71) |
| Migraine with aura | 5.40 (2.05–17.97) | 5.32 (1.98–14.33) | 1.46 (0.86–2.50) | 1.51 (0.88–2.57) |
| Migraine without aura or unspecified | 2.32 (1.50–3.67) | 2.10 (1.32–3.34) | 1.59 (1.20–2.13) | 1.36 (1.01–1.82) |
| Primary migraine medication | 1.49 (1.31–1.68) | 1.47 (1.28–1.68) | 0.93 (0.86–1.01) | 0.90 (0.82–1.00) |
| Triptans | 1.59 (1.39–1.82) | 1.57 (1.36–1.81) | 0.94 (0.86–1.03) | 0.92 (0.84–1.01) |
| Ergotamine | 0.97 (0.69–1.35) | 0.97 (0.68–1.38) | 0.89 (0.93–1.09) | 0.87 (0.71–1.07) |
| Secondary migraine medication | 1.48 (1.35–1.62) | 1.30 (1.17–1.13) | 1.05 (0.99–1.10) | 0.94 (0.89–1.00) |
Notes: Adjusted for gender, age, education, diabetes, hypertension, alcohol related disorder, chronic obstructive pulmonary disease, depression, use of oral contraceptives, hormone replacement therapy, and antithrombotic medication (acetylsalicylic acid, clopidogrel, and warfarin) and statins prior to diagnosis;
*
STEMI, non-STEMI and unspecified.
Abbreviation: STEMI, ST-elevation myocardial infarction.