Table 2.

Univariable and multivariable analyses of prognostic parameters for survival in Ren Ji cohort 2 patients with pancreatic ductal adenocarcinoma (PDAC).

	Univariable analysis			Multivariable analysis
Prognostic parameter	HR	95% CI	P value	HR	95% CI	P value
Expression of DKK1 (high vs. low)	1.828	1.354–2.467	0.000	1.623	1.189–2.215	0.002
Age (≥ 65 vs. <65)	1.314	1.000–1.727	0.050	−	−	−
Gender (male vs. female)	0.861	0.655–1.132	0.283	−	−	−
TNM stage (III , IV vs.I , II)	1.827	1.326–2.518	0.000	1.480	0.961–2.279	0.075
Tumor Size (> 3 cm vs. ≤ 3 cm)	1.753	1.313–2.341	0.000	1.353	0.995–1.839	0.054
T classification (T3, 4 vs. T1, 2)	2.014	1.252–3.240	0.004	1.429	0.868–2.352	0.160
Lymph node metastasis (present vs. absent)	1.686	1.279–2.223	0.000	1.408	1.054–1.881	0.021
Distant metastasis (present vs. absent)	1.858	1.201–2.874	0.005	0.983	0.554–1.747	0.954
Vascular invasion (present vs. absent)	1.830	1.195–2.802	0.005	1.504	0.959–2.359	0.075
Perineural invasion (present vs. absent)	1.147	0.876–1.502	0.319	−	−	−
Tumor location (head vs. body/tail)	1.039	0.782–1.380	0.791	−	−	−
Histology (well/moderate vs. poor)	1.682	1.274–2.222	0.000	1.490	1.115–1.990	0.007

Note. HR: Hazard ratio; CI: Confidence interval. The bold number represents the P-values with significant differences.