Schematic representation of the TAF1 and MLL3 proteins indicating the relative locations of functional domains. Somatic mutations identified among the 16 discovery screen tumors and 47 prevalence screen tumors are represented by squares. The amino acid (aa) length of the protein is indicated. Domain abbreviations: TBBD (TATA box-binding protein binding), HAT (Histone acetyltransferase), HMG (High Mobility Group), BD (Bromodomain), RAP74 (RNA polymerase II-associating protein 74), AT hook (Adenine Thymine hook), PHD (Plant Homeodomain), ZFD (Zinc Finger Domain), FYR (F/Y rich), SET (Su(var)3–9 and Enhancer-of-zeste and Trithorax).