. Author manuscript; available in PMC: 2017 Sep 6.

Published in final edited form as: Exp Eye Res. 2015 Mar 25;134:80–89. doi: 10.1016/j.exer.2015.03.018

Table 1. Differential expression of TLR4, TLR5 and TLR 9 mRNA and protein.

TLR Expression in Response to Dry Eye Conditions
TLR	In Vitro		Cadaver Corneas or Human Subjects
TLR	Hyperosmolar Stress	Dry Eye Associated Cytokines	Organ Desiccation Model	Conjunctival Impression Cytology Dry Eye Subjects
TLR4	^↑ TLR4 mRNA ^↓TLR4 Protein	No Effect on TLR4	^↑ TLR4 mRNA ^#NS ^↑TLR4 protein	^#NS ^↑TLR4 mRNA
TLR5	No Effect on TLR5	No Effect on TLR5	^↑ TLR5 mRNA	No Effect on TLR5
TLR9	^↓ TLR 9 mRNA ^↓ TLR 9 protein	No Effect on TLR9	^↓ TLR 9 mRNA ^#NS^↓ TLR 9 protein	^↓ TLR 9 mRNA

^↑

Up-regulation

^↓

Down-regulation

Non-significant (NS) change in expression