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. 2017 Aug 29;10:4239–4250. doi: 10.2147/OTT.S136992

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© 2017 Creelan et al. This work is published and licensed by Dove Medical Press Limited

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Effect of continuous oral omaveloxolone upon Nrf2 target genes.

Notes: mRNA expression was normalized to two housekeeping genes and then pre-dose level. (A) Expression over timepoints, 5 mg cohort example (n=3). Bars represent mean with standard error. *P<0.05 for Wilcoxon signed-rank test of whether post-dose timepoints exceeded normalized pre-dose level of 1. (B) Expression by dose level for samples collected at day 28, n=3 for each cohort. Bars represent mean with standard error. *P<0.05 for one-sided t-test for comparison between indicated groups.

Abbreviations: Ferritin H, ferritin heavy subunit; mRNA, messenger RNA; Nrf2, nuclear factor erythroid 2-related factor 2; PGDH, prostaglandin dehydrogenase 1.