Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 29;10:4239–4250. doi: 10.2147/OTT.S136992

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Creelan et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Representative images of NT and iNOS from limited on-treatment tumor biopsies for two patients with metastatic melanoma.

Notes: (A) Punch skin biopsy at day +35 from patient in 10 mg cohort showed overall decrease in expression of nitration markers compared to baseline. (B) Bone metastasis biopsy at day +105 from patient in 5 mg cohort showed little difference in NT or iNOS expression compared to baseline. Archival bone samples were difficult to evaluate due to prior decalcification and scant tumor. Serial biopsies for additional patients were not available. Original magnification 4×.

Abbreviations: iNOS, inducible isoform of nitric oxide synthase; NT, nitrotyrosine.